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Article

Clinicopathological and immunohistochemical characterization of melanotic neuroectodermal tumour of infancy with special focus on BRAFV600E and β-catenin expression.

Oral surgery, oral medicine, oral pathology and oral radiology - 1 Nov 2026

N Sivakumar, Trimukhe Akshay, Jot Kiran, Kaur Sharanjeet, Surya Varun, Mishra Deepika, Nayyar Vivek

Abstract excerpt

BACKGROUND: Melanotic neuroectodermal tumour of infancy is primarily treated by complete surgical excision; however, recurrence rates range from 20% to 25%. Recurrent lesions often exhibit more aggressive behaviour, which complicates surgical management and may preclude radical resection, thereby necessitating the use of adjuvant therapies. The limited molecular characterization of MNTI has impeded the...

Read the complete abstract on PubMed

Topics

Humans
beta Catenin
Proto-Oncogene Proteins B-raf
Neuroectodermal Tumor, Melanotic
Immunohistochemistry

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Male

Infant

Biomarkers, Tumor

Mutation

Source

Identifiers

PMID: 42401499
DOI: 10.1016/j.oooo.2026.05.016

Genes

CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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