Article
Thyroid cancer-associated EZH1 Q571R mutation drives chromatin compaction and H3K27me3 invasion into active chromatin.
Molecular cell - 16 Jul 2026
Kim Hanbyeol, Kim Do-Gyun, Ha Seongyun, Jang Jun-Young, Vitorino Francisca N de L, Gongora Joanna M, Kim Woochul, Oh Yoonji, Park Gyeongsik, Kang Hyeji, Im Soo-Hyun, Jung Chan Kwon, Kim Seon-Young, Jung Inkyung, Won Jae-Kyung, Garcia Benjamin A, Kim Su-Jin, Lee Kyu Eun, Ryu Je-Kyung, Lee Chul-Hwan
Abstract excerpt
Dysregulation of Polycomb Repressive Complex 2 (PRC2) contributes to cancer. Of its catalytic subunits, Enhancer of Zeste (EZH) 1 and EZH2, EZH2 mutations are extensively studied, but the role of EZH1 in cancer remains largely unexplored. Here, we investigate the thyroid cancer-associated EZH1Q571R mutation and uncover a mechanism that extends beyond catalytic gain of function. Using biochemical, single-molecule,...
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