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Hierarchical analysis of metabolic phenotype reveals distinct microbiota and circulatory transcriptome in metabolic dysfunction-associated steatotic liver disease.

Gene - 10 Nov 2026

Tung Chien-Yi, Lin Yi-Hsuan, Chang Ya-Yuan, Ruan Jhen-Wei, Chen Pei-Chen, Chen Chian-Feng, Yeh Hsiao-Yun, Shen Hsiao-Chin, Tsai Hung-Cheng, Li Tzu-Hao, Su Chien-Wei, Yang Ying-Ying, Hou Ming-Chih

Abstract excerpt

AIM: To investigate how visceral adiposity and insulin resistance, defined respectively by visceral adiposity index (VAI) and triglyceride-glucose (TyG) index, jointly influence gut microbiota composition and immune transcriptomes in metabolic dysfunction-associated steatotic liver disease (MASLD), and to explore potential mechanistic pathways. METHODS: We enrolled 169 adults stratified by VAI, controlled...

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Fatty Liver
Gastrointestinal Microbiome
Gene Expression Profiling
Insulin Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Metabolic Diseases

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PMID: 42392328
DOI: 10.1016/j.gene.2026.150292

Genes

IL6
PTGS1
SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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