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Article

Blood Manganese and Risk of Squamous Cell Carcinomas of the Head and Neck.

JAMA otolaryngology-- head & neck surgery - 1 Aug 2026

Clay Benjamin, Bashir Nasir, Burgess Stephen, Carter Paul

Abstract excerpt

Importance: Squamous cell carcinomas of the oral cavity (OCSCC), oropharynx (OPSCC), hypopharynx (HPSCC), and larynx (LSCC) are the most common forms of head and neck cancer globally. Epidemiological studies have identified variations in blood trace metal concentrations as potential risk factors for the development of these cancers, but these studies are susceptible to multiple biases. Objective: To determine if...

Topics

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Carcinoma, Squamous Cell
Genome-Wide Association Study
Head and Neck Neoplasms
Manganese
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Squamous Cell Carcinoma of Head and Neck

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Identifiers

PMID: 42390852
DOI: 10.1001/jamaoto.2026.1749
PMCID: PMC13329739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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