Genome-wide association studies of infant and toddler temperament in European and multi-ancestry populations.

doi:10.1038/s41562-026-02486-5

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Article

Genome-wide association studies of infant and toddler temperament in European and multi-ancestry populations.

Nature human behaviour - 1 Sept 2026

Hollowell Anja, Gui Anna, Wigdor Emilie, Morgan Morgan J, Hannigan Laurie J, Corfield Elizabeth C, Pool René, Bruins Susanne, Ask Helga, Middeldorp Christel M, Pourcain Beate St, Bartels Meike, Boomsma Dorret I, Hartman Catharina A, Noda Aoi, Takahashi Ippei, Ishikuro Mami, Obara Taku, Kuriyama Shinichi, Mufford Mary S, Lake Marilyn T, Stein Dan J, Zar Heather J, Hoffman Nadia, Robinson Elise B, Børglum Anders D, Zhang Xinhe, Warrier Varun, Arichi Tomoki, Johnson Mark H, Dudbridge Frank, Sanders Stephan J, Havdahl Alexandra, Ronald Angelica

Abstract excerpt

Early temperament, such as socio-emotional development and activity level, varies widely, yet its underlying biological associations are not understood. We identified genetic variation associated with infant and toddler temperament using genome-wide association meta-analyses. We studied parent-rated emotionality, activity, shyness and sociability (n = 43,963-72,663) in the second and third postnatal years and a...

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Topics

Child, Preschool
Female
Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Infant

Male

Emotions

Genome-Wide Association Study

Polymorphism, Single Nucleotide

Shyness

Temperament

White People

Source

Open in PubMed Open full text

Identifiers

PMID: 42386913
DOI: 10.1038/s41562-026-02486-5
PMCID: PMC13590410

Genes

MR1
RHEBL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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