Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting autoreactive B cells in rheumatoid arthritis through MHC class I-presented BCR-derived neo-epitopes.

Journal of autoimmunity - 1 Aug 2026

van de Wetering Renee, Kampstra Arieke S B, Kester Michel G D, Tjokrodirijo Rayman T N, de Ru Arnoud H, van Veelen P A, Fehres Cynthia M, Heemskerk Mirjam H M, Toes René E M

Abstract excerpt

Somatic mutations can generate neoantigens recognized by CD8+ T cells, enabling targeted elimination of mutated cells. Currently established B cell-targeting therapies in human B cell-mediated autoimmune diseases lack specificity and fail to achieve durable remission. Since autoreactive B cells often express B cell receptors (BCRs) that have undergone extensive somatic hypermutations (SHM), we hypothesized that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen Presentation
Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autoantibodies

Share to CD8-Positive T-Lymphocytes

Share to Epitopes, B-Lymphocyte

Share to Histocompatibility Antigens Class I

Share to Lymphocyte Activation

Share to Receptors, Antigen, B-Cell

Source

Identifiers

PMID: 42378906
DOI: 10.1016/j.jaut.2026.103581

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting autoreactive B cells in rheumatoid arthritis through MHC class I-presented BCR-derived neo-epitopes.PMID 42378906Read ↗

N-Glycosylation Site Analysis of Citrullinated Antigen-Specific B-Cell Receptors Indicates Alternative Selection Pathways During Autoreactive B-Cell DevelopmentSemantic proximity Read ↗

Autoantigen-specific CD8+ T-cell signature in Rheumatoid ArthritisSemantic proximity Read ↗

Pathogenic Citrulline‐Multispecific B Cell Receptor Clades in Rheumatoid ArthritisSemantic proximity Read ↗

Autoreactive B cells in rheumatoid arthritis consist of activated CXCR3+ memory B cells and plasmablastsSemantic proximity Read ↗

Antigen-specific Fab profiling achieves molecular-resolution analysis of human autoantibody repertoires in rheumatoid arthritisSemantic proximity Read ↗

Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiologySemantic proximity Read ↗

Beyond autoantibodies: Biological roles of human autoreactive B cells in rheumatoid arthritis revealed by whole transcriptome profilingSemantic proximity Read ↗

Autoreactive B cells in rheumatoid arthritis include mainly activated CXCR3+ memory B cells and plasmablastsSemantic proximity Read ↗

Affinity Maturation of the Anti–Citrullinated Protein Antibody Paratope Drives Epitope Spreading and Polyreactivity in Rheumatoid ArthritisSemantic proximity Read ↗

Citrullination only infrequently impacts peptide binding to HLA class II MHC.Semantic proximity Read ↗

Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA‐SequencingSemantic proximity Read ↗

Citrullination modulates antigen processing and presentation by revealing cryptic epitopes in rheumatoid arthritisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.