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Article

Association of AQP5 gene variants and mRNA expression with caries severity in a dental practice cohort: a randomized trial.

Scientific reports - 30 Jun 2026

Bitter Janusch, Pakosch-Nowak Daria, Adamzik Michael, Ziehe Dominik, Orlowski Jennifer, Koos Bjoern, Kunkel Martin, Rump Katharina, Baumann Markus

Abstract excerpt

Aquaporin 5 (AQP5) is crucial for salivary secretion, composition and enamel mineralization. Genetic variations in AQP5 may influence susceptibility to dental diseases such as caries. This study investigated the association between AQP5 single nucleotide polymorphisms (SNPs), AQP5 mRNA expression, and caries severity in a dental practice cohort. A total of 246 patients were enrolled. Caries experience was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42374058
DOI: 10.1038/s41598-026-59514-7
PMCID: PMC13315598

Genes

AQP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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