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Article

Effects of enamel matrix genes on dental caries are moderated by fluoride exposures.

Human genetics - 1 Feb 2015

Shaffer John R, Carlson Jenna C, Stanley Brooklyn O C, Feingold Eleanor, Cooper Margaret, Vanyukov Michael M, Maher Brion S, Slayton Rebecca L, Willing Marcia C, Reis Steven E, McNeil Daniel W, Crout Richard J, Weyant Robert J, Levy Steven M, Vieira Alexandre R, Marazita Mary L

Abstract excerpt

Dental caries (tooth decay) is the most common chronic disease, worldwide, affecting most children and adults. Though dental caries is highly heritable, few caries-related genes have been discovered. We investigated whether 18 genetic variants in the group of non-amelogenin enamel matrix genes (AMBN, ENAM, TUFT1, and TFIP11) were associated with dental caries experience in 13 age- and race-stratified samples from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25373699
DOI: 10.1007/s00439-014-1504-7
PMCID: PMC4293346

Genes

TUFT1
AMBN
TFIP11
ENAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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