Article
Aquaporin 5 Interacts with Fluoride and Possibly Protects against Caries.
PloS one - 1 Jan 2015
Anjomshoaa Ida, Briseño-Ruiz Jessica, Deeley Kathleen, Poletta Fernardo A, Mereb Juan C, Leite Aline L, Barreta Priscila A T M, Silva Thelma L, Dizak Piper, Ruff Timothy, Patir Asli, Koruyucu Mine, Abbasoğlu Zerrin, Casado Priscila L, Brown Andrew, Zaky Samer H, Bayram Merve, Küchler Erika C, Cooper Margaret E, Liu Kai, Marazita Mary L, Tanboğa İlknur, Granjeiro José M, Seymen Figen, Castilla Eduardo E, Orioli Iêda M, Sfeir Charles, Owyang Hongjiao, Buzalaf Marília A R, Vieira Alexandre R
Abstract excerpt
Aquaporins (AQP) are water channel proteins and the genes coding for AQP2, AQP5, and AQP6 are clustered in 12q13. Since AQP5 is expressed in serous acinar cells of salivary glands, we investigated its involvement in caries. DNA samples from 1,383 individuals from six groups were studied. Genotypes of eight single nucleotide polymorphisms covering the aquaporin locus were tested for association with caries...
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