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Article

Identification of Hub Genes, Single-Nucleotide Polymorphisms, and Potential Drug Targets In Breast Cancer Using Transcriptomic Analysis.

Journal of visualized experiments : JoVE - 9 Jun 2026

Jia Xiaobo, Su Hui, Zhang Jiaxin, Liu Zhao

Abstract excerpt

HER2-positive (HER2+) breast cancer often develops resistance to therapies like Lapatinib, potentially involving mitochondrial metabolic and redox reprogramming. This study aimed to identify mitochondrial oxidative stress-related genes (MOS-DEGs) as biomarkers of resistance and to characterize their functional nsSNPs and structural impacts. RNA-seq datasets (GSE231524, GSE231525) were analyzed using DESeq2 to...

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Aminohydrolases
Breast Neoplasms
Gene Expression Profiling
Methylenetetrahydrofolate Dehydrogenase (NADP)
Multifunctional Enzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxidative Stress

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 42372043
DOI: 10.3791/70964

Genes

MTHFD2
PRDX3
MOS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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