Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive analysis of breast cancer oxidative stress related gene signature: a combination of bulk and single-cell RNA sequencing analysis.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2025

Shao Yuheng, Zhang Yumeng, Chen Jie, Yang Liang, Wu Meihong, Fan Zhiyuan, Zhuang Zhigang

Abstract excerpt

Oxidative stress influences the tumor microenvironment, driving breast cancer progression and drug resistance. This study aimed to develop a prognostic gene signature based on oxidative stress-related genes (OSRGs) to assess patient outcomes and immune status. UCSC Xena ( http://xena.ucsc.edu/ ) and GEO ( https://www.ncbi.nlm.nih.gov/geo/ ) databases were used to obtain RNA-seq data and corresponding clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Regulatory Networks

Share to Oxidative Stress

Share to Sequence Analysis, RNA

Share to Single-Cell Analysis

Share to Transcriptome

Share to Tumor Microenvironment

Source

Identifiers

PMID: 40274661
DOI: 10.1007/s00335-025-10130-2

Genes

TFAP2B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive analysis of breast cancer oxidative stress related gene signature: a combination of bulk and single-cell RNA sequencing analysis.PMID 40274661Read ↗

Oxidative stress genes define two subtypes of triple-negative breast cancer with prognostic and therapeutic implicationsSemantic proximity Read ↗

Oxidative Stress Response Biomarkers of Ovarian Cancer Based on Single-Cell and Bulk RNA SequencingSemantic proximity Read ↗

Identification of Breast Cancer Subtypes Based on Endoplasmic Reticulum Stress-Related Genes and Analysis of Prognosis and Immune Microenvironment in Breast Cancer PatientsSemantic proximity Read ↗

Role of hypoxia-related genes in breast cancer based on a comprehensive analysis of scRNA-seq and bulk RNA-seqSemantic proximity Read ↗

Development and validation of a novel endoplasmic reticulum stress-related lncRNA prognostic signature and candidate drugs in breast cancerSemantic proximity Read ↗

Application of single-cell RNA sequencing analysis of novel breast cancer phenotypes based on the activation of ferroptosis-related genes.Semantic proximity Read ↗

Delving into the Heterogeneity of Different Breast Cancer Subtypes and the Prognostic Models Utilizing scRNA-Seq and Bulk RNA-SeqSemantic proximity Read ↗

Establishment and external verification of an oxidative stress-related gene signature to predict clinical outcomes and therapeutic responses of colorectal cancerSemantic proximity Read ↗

The construction of a breast cancer prognostic model by combining genes related to hypoxia and endoplasmic reticulum stress.Semantic proximity Read ↗

Prognostic Analysis of Patients with Breast Cancer Based on Tumor Mutational Burden, DNA Damage Repair Genes, and Immune InfiltrationSemantic proximity Read ↗

Identification of molecular characteristics associated with disulfidptosis and ferroptosis-related genes in breast cancer, along with immune cell infiltration Analysis and Development of a prognostic risk modelSemantic proximity Read ↗

Integrated Analysis of Single-Cell and Bulk RNA-Seq Data reveals that Ferroptosis-Related Genes Mediated the Tumor Microenvironment predicts Prognosis, and guides Drug Selection in Triple-Negative Breast CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.