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Compound heterozygous variants in F7 gene causing severe factor VII deficiency without bleeding: A genotypic and laboratory analysis.

Blood cells, molecules & diseases - 1 Sept 2026

Wang Fengjiao, Liu Meina, Jin Yanhui, Wu Conglian, Lu Yifan, Qin Langyi, Wang Mingshan, Yang Lihong

Abstract excerpt

Coagulation factor VII (FVII) is a vitamin K-dependent glycoprotein and serves as a key initiator of the extrinsic coagulation pathway. Hereditary FVII deficiency is an autosomal recessive genetic disorder with a highly heterogeneous bleeding phenotype. It is the most prevalent among rare hereditary bleeding disorders. Among the various genotypes, complex heterozygous variants are of particular importance in...

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Identifiers

PMID: 42361596
DOI: 10.1016/j.bcmd.2026.103025

Genes

F7

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