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Article

Impact of ΔF508 CFTR mutation on diaphragm function during acute inflammation.

American journal of physiology. Cell physiology - 1 Aug 2026

Ostadan Fatemeh, Gusev Ekaterina, Liang Feng, De Sanctis Juan Bautista, Radzioch Danuta, Petrof Basil J

Abstract excerpt

Cystic fibrosis is caused by cystic fibrosis transmembrane conductance regulator (CFTR) mutations and is associated with skeletal muscle dysfunction. Prior work showed exaggerated inflammatory activation of proteolysis pathways in the diaphragms of CFTR-null mice. However, the effects of the more clinically relevant ΔF508 (DF-CFTR) mutation on diaphragm function are unknown. Homozygous DF-CFTR mice (Cftrtm1EUR)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42360227
DOI: 10.1152/ajpcell.00018.2026

Genes

CFTR
IL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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