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Article

Determinants of Dengue Serotype Shifts: A Narrative Multifactorial Perspective.

Viruses - 18 Jun 2026

Suppiah Jeyanthi, Rajendiran Sakshaleni, Rashid Siti Aishah, Ab Hamid Nurulhusna, Zulkifli Murni Maya Sari, Mohd Zain Rozainanee

Abstract excerpt

Dengue Virus (DENV) circulates as four antigenically distinct serotypes whose dominance fluctuates over time in many endemic regions, a phenomenon known as serotype shift that is frequently associated with large outbreaks and increased disease severity. This review, through a synthesis of epidemiological, virological, immunological, entomological, and environmental evidence, observes that serotype shift likely...

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Identifiers

PMID: 42357692
DOI: 10.3390/v18060683
PMCID: PMC13308309

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