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Article

Irritable bowel syndrome subtype predicts treatment response and defines distinct mechanistic phenotypes in OAB-IBS comorbidity: a prospective observational study.

World journal of urology - 25 Jun 2026

Sun Qi, Gao Yubo, Shi Xinhang, Xie Ming, Zheng Jun, Yang Xunguo, Yang Lin, Liao Rulin, Ma Cunzhen, Li Zhuohang, Sun Boyuan, Cheng Bisheng, Wu Peng

Abstract excerpt

PURPOSE: To investigate the heterogeneity of treatment response in patients with concomitant Overactive Bladder (OAB) syndrome and Irritable Bowel Syndrome (IBS), including diarrhea-predominant (IBS-D), constipation-predominant (IBS-C), and mixed-type (IBS-M), by stratifying outcomes by both treatment strategy and IBS subtype. We hypothesized that IBS subtype would predict therapeutic response and define distinct...

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PMID: 42347939
DOI: 10.1007/s00345-026-06548-1

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