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Article

Behavioral variant frontotemporal dementia associated with a NEK1 missense variant: exploring a possible phenotypic association.

Neurogenetics - 23 Jun 2026

Totuk Ozlem, Sahin Sevki

Abstract excerpt

NEK1 variants are recognized genetic contributors to amyotrophic lateral sclerosis (ALS) and have occasionally been reported within the ALS-frontotemporal dementia (FTD) spectrum. However, their association with isolated behavioral variant frontotemporal dementia (bvFTD) remains unclear. Here, we describe a 69-year-old man who developed progressive behavioral symptoms beginning in his early 60s. Cognitive...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42334646
DOI: 10.1007/s10048-026-00916-0

Genes

NEK1
GRN
MAPT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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