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Article

Construction and phenotypic analysis of a low molecular weight tyrosine phosphatase mutant in Streptococcus suis serotype 2.

BMC veterinary research - 19 Jun 2026

Wu Qianqian, Sun Yanxia, Ping Jiawen, Lu Bingbing, Liu Dekun, Zhang Li, Wang Yutao, Ni Hua

Abstract excerpt

BACKGROUND: Streptococcus suis (S. suis) is a major zoonotic pathogen that causes severe infections in both pigs and humans. Low-molecular-weight protein tyrosine phosphatases (LMWPTPs) are a conserved family of enzymes involved in capsule synthesis and the pathogenicity of various Gram-positive pathogens, but their functional role in S. suis 2 remains unclear. RESULTS: We constructed a homologous Lmwptp deletion...

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Topics

Streptococcus suis
Protein Tyrosine Phosphatases
Animals
Mice
Virulence
Streptococcal Infections

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Humans

Molecular Weight

Mutation

Bacterial Capsules

Female

Source

Open in PubMed Open full text

Identifiers

PMID: 42321725
DOI: 10.1186/s12917-026-05632-3
PMCID: PMC13528105

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