Long-term competition experiments reveal limited adaptive evolution in human cell lines.

Abstract excerpt

Cancer progression is driven by somatic evolution, where mutations and selection generate more adapted clones. However, it remains unclear whether human cells continue to evolve under stable laboratory conditions or instead reach a near-optimal state. We addressed this using two human cell lines, HeLa and 293, with isogenic subpopulations differing only by a fitness-neutral marker (inducible GFP expression)....

Topics

• Humans
• HeLa Cells
• Green Fluorescent Proteins
• Mutation
• Cell Competition
• HEK293 Cells