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FLNA, a disulfidptosis-related gene, modulates tumor immunity and progression in colorectal cancer

26 Jul 2025

Abstract excerpt

Disulfidptosis represents a novel type of regulated cell death induced by excessively high intracellular levels of cystine. Targeting disulfide imbalance is considered a promising treatment approach for colorectal cancer (CRC). However, the involvement of disulfidptosis in CRC immunotherapy is undefined. Unsupervised clustering was applied to The Cancer Genome Atlas (TCGA) datasets to classify...

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PMID: 40713509
DOI: 10.1186/s11658-025-00761-3

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