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Article

MEFV variants as phenotypic modifiers in ankylosing spondylitis: a genetic interaction analysis with HLA-B27.

Acta clinica Belgica - 1 Oct 2026

Irmak Kaya Zeynep, Kaşifoğlu Timuçin

Abstract excerpt

BACKGROUND: MEFV mutations are prevalent in Mediterranean populations, yet their potential role in modulating ankylosing spondylitis (AS) remains unclear. We investigated whether MEFV variants act as susceptibility factors or modify disease phenotype via interaction with HLA-B27. METHODS: In this cross-sectional study, 129 AS patients meeting the modified New York criteria, 51 rheumatoid arthritis controls, and...

Read the complete abstract on PubMed

Topics

Humans
Spondylitis, Ankylosing
HLA-B27 Antigen
Male
Female
Cross-Sectional Studies
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Pyrin

Middle Aged

Phenotype

Case-Control Studies

Mutation

Source

Identifiers

PMID: 42319388
DOI: 10.1080/17843286.2026.2691018

Genes

MEFV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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