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Contribution of mutational resistance mechanisms and acquired β-lactamases to cefiderocol/xeruborbactam susceptibility in Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 10 Dec 2025

González-Pinto Lucía, Gomis-Font María Antonia, Pérez-Rodríguez Gloria, Blanco-Martín Tania, Rodríguez-Pallares Salud, Sánchez-Peña Lucía, Beceiro Alejandro, Bou Germán, Jeannot Katy, Oliver Antonio, Arca-Suárez Jorge

Abstract excerpt

Cefiderocol/xeruborbactam is a novel β-lactam/β-lactamase inhibitor combination in which the siderophore-cephalosporin cefiderocol is paired with xeruborbactam, a broad-spectrum inhibitor that targets class A to D β-lactamases. We evaluated the contribution of Pseudomonas aeruginosa resistance mechanisms to cefiderocol/xeruborbactam susceptibility. A panel of 61 P. aeruginosa PAO1 derivatives was tested,...

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PMID: 41118352
DOI: 10.1128/aac.01048-25
PMCID: PMC12691625

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