Article
A k-mer-based genome-wide association study approach empowering gene mining in polyploids.
Nature genetics - 1 Jul 2026
Chen Shuai, Liu Xinlong, Qu Shenyang, Song Yuhan, Chai Kun, Liu Hongbo, Zhang Yuebin, Xia Zhongqiang, Li Xiaofeng, Wang Jungang, Zhang Muqing, Li Hongbo, Chen Guo-Bo, Maliepaard Chris, Zhang Xingtan
Abstract excerpt
Genome-wide association studies in complex polyploids are hindered by genotyping ambiguity and allele dosage complexity. Here we present KMERIA, a k-mer-based framework specifically designed to address these challenges, enabling efficient genotyping and robust association mapping in complex polyploid genomes. Rigorous benchmarking with simulated and empirical datasets demonstrates that KMERIA surpasses existing...
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