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Targeted cleavage site mutations in the Gn precursor enable efficient generation of replication-competent rVSV-based surrogates for emerging nairoviruses.

Emerging microbes & infections - 1 Dec 2026

Jain Shilpi, Marot Stéphane, Karaaslan Elif, Sajadi Mohammad M, Baykam Nurcan, Yapar Derya, Shoemaker Trevor, Montgomery Joel M, Spiropoulou Christina F, Albariño César G, Bergeron Éric

Abstract excerpt

Orthonairoviruses are rapidly emerging, tick-borne viruses including Crimean Congo hemorrhagic fever virus (CCHFV), a highly pathogenic virus requiring biosafety level 4 (BSL-4) containment. Recently discovered nairoviruses such as Yezo virus (YEZV) cause febrile illness and are spreading across East Asia. No vaccines or therapeutics exist for these emerging nairoviruses. Recombinant vesicular stomatitis virus...

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PMID: 42281293
DOI: 10.1080/22221751.2026.2678640
PMCID: PMC13267033

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