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Integrating phenotypic and ceRNA network analyses reveals potential hypoxia adaptation mechanisms in Tibetan sheep skeletal muscles.

Genomics - 1 Jul 2026

Zhao Pengfei, Wandai Cairang, Ma Guangyu, Chen Xi, Ma Xujun, Ma Xiong

Abstract excerpt

This study examines the impact of altitude on skeletal muscle adaptation in Tibetan sheep and the associated molecular mechanisms. A total of fifteen Tibetan sheep were used, with five each at low (L), middle (M), and high (H) altitude. Myofibril diameter, intramuscular fat (IMF) content, and mRNA and lncRNA expression profiles in the biceps femoris were analyzed. Based on this, a competitive endogenous RNA...

Topics

Animals
Sheep
RNA, Competitive Endogenous
Muscle, Skeletal
Adaptation, Physiological
Altitude
Hypoxia
RNA, Long Noncoding
Gene Regulatory Networks
MicroRNAs
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42269883
DOI: 10.1016/j.ygeno.2026.111276

Genes

FOXO1
TRIM63

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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