Article
Effect of green mediterranean diet on serum folate and its interaction with genetic variation in folate metabolism: The DIRECT PLUS 18-month dietary randomized controlled trial.
Clinical nutrition (Edinburgh, Scotland) - 1 Aug 2026
Zelicha Hila, Keller Maria, Meir Anat Yaskolka, Rinott Ehud, Tsaban Gal, Kaplan Alon, Hoffmann Anne, Blüher Matthias, Ceglarek Uta, Isermann Berend, Stumvoll Michael, Shelef Ilan, Hu Frank B, Stampfer Meir J, Kovacs Peter, Shai Iris
Abstract excerpt
BACKGROUND: & Aims: Folate metabolism can be regulated by diet and genetic variation, particularly Methylenetetrahydrofolate reductase (MTHFR) rs1801133 polymorphism. We explored the effect of plant-based green-Mediterranean (green-MED) diet on serum folate and whether this effect varies by genetic variation in folate metabolism over 18-months METHODS: In the DIRECT-PLUS trial, 294 participants were randomized to...
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