Article
Genetic association and computational analysis of CYP2R1 gene polymorphisms rs2060793 and rs12794714 with vitamin D deficiency and acute myocardial infarction in the Bangladeshi population: A case control study.
PloS one - 1 Jan 2026
Akter Sadia, Ibrahim Md Nazid Bin, Mahmud Zimam, Tamanna Sonia, Shawon Md Shakhawat Hossain, Ansari Farzana, Howlader Md Zakir Hossain
Abstract excerpt
Acute myocardial infarction (AMI) remains a leading cause of cardiovascular morbidity and mortality worldwide. Emerging evidence highlights vitamin D as a critical determinant of cardiovascular health. The CYP2R1 gene encodes the key 25-hydroxylase enzyme responsible for converting vitamin D to its principal circulating metabolite, 25-hydroxyvitamin D. However, the influence of CYP2R1 polymorphisms on AMI...
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