Article
In vivo binding by Arabidopsis SPLICING FACTOR 1 shifts 3' splice-site choice, regulating circadian rhythms and immunity in plants.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jun 2026
Agrofoglio Yamila Carla, Iglesias María José, de Leone María José, Hernando Carlos Esteban, Lewinski Martin, Torres Sol Belén, Contino Giuliana, Köhnke Kim Joelle, Yanovsky Marcelo Javier, Staiger Dorothee, Mateos Julieta Lisa
Abstract excerpt
Alternative splicing expands proteome diversity and enables phenotypic plasticity across eukaryotes. In plants, mutations in spliceosomal components impair development and stress responses, but the molecular mechanisms remain unclear. Here, we define the molecular function of SPLICING FACTOR 1 (AtSF1) in Arabidopsis thaliana using individual-nucleotide resolution UV crosslinking and immunoprecipitation combined...
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