Genome-wide modelling of plant transcription factor binding captures regulatory variants associated with phenotypic traits.

Abstract excerpt

The sequence-specific recognition of cis-regulatory elements (CRE) by transcription factors (TF) propagates genotype information to phenotypes. Understanding how genetic variation affects gene regulation remains limited by the diversity and complexity of CRE interactions. Here, we address this challenge using an explainable multi-label deep learning model trained on A. thaliana DNA-binding data to capture how CRE...

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