Article
SNooPy: a statistical framework for long-read metagenomic variant calling.
Nucleic acids research - 20 May 2026
Faure Roland, Faure Ulysse, Truong Tam, Derzelle Alessandro, Lavenier Dominique, Flot Jean-François, Quince Christopher
Abstract excerpt
Current long-read single-nucleotide variant callers were designed primarily for genomic data-particularly human genomes. While some have been used on metagenomic data, their underlying assumptions and training procedures fail to account for the inherent complexity of metagenomic samples. To date, no long-read variant caller has been purpose-built for metagenomic applications. To address this gap, we present...
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