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Article

Management and risk mitigation strategies for FLT3-ITD+ acute myeloid leukemia: clinical utilization of quizartinib.

Leukemia & lymphoma - 1 Aug 2026

Horsch Laurie, Baron Jeffrey, Sung Pamela J, Wang Eunice S

Abstract excerpt

Acute myeloid leukemia (AML) with FMS-like tyrosine kinase 3 (FLT3) mutations represent a clinically aggressive subtype of AML characterized by a poor prognosis and high frequency of relapse. Although several FLT3 inhibitors exist, they differ in their side effects, potency and clinical use. Quizartinib is a potent next generation FLT3 inhibitor with a risk of QTc-prolongation necessitating a Risk Evaluation and...

Topics

Humans
fms-Like Tyrosine Kinase 3
Phenylurea Compounds
Leukemia, Myeloid, Acute
Benzothiazoles
Antineoplastic Combined Chemotherapy Protocols
Mutation
Protein Kinase Inhibitors
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Treatment Outcome

Disease Management

Tandem Repeat Sequences

Source

Identifiers

PMID: 42217224
DOI: 10.1080/10428194.2026.2676107

Genes

FLT3
CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-42217224-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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