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Article

Pangenome analysis of Proteus mirabilis reveals lineage-specific antimicrobial resistance profiles and discordant genotype-phenotype correlations.

Antimicrobial agents and chemotherapy - 1 Jul 2026

Deka Namrata, Brauer Aimee L, Connerton Katherine, Hanson Blake M, Walker Jennifer N, Armbruster Chelsie E

Abstract excerpt

Urinary tract infections (UTIs) impose a large healthcare burden, with escalating antimicrobial resistance (AMR), and treatment failure. Proteus mirabilis is an undercharacterized and challenging UTI pathogen due to intrinsic resistance and biofilm formation. To understand P. mirabilis population genomics, we combined pangenome analysis, in silico AMR prediction, and phenotypic antimicrobial susceptibility...

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Identifiers

PMID: 42210697
DOI: 10.1128/aac.01768-25
PMCID: PMC13321803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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