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Article

Osimertinib plus selumetinib in patients with EGFR-mutated advanced NSCLC with BRAF alterations post-progression on first-line osimertinib: ORCHARD.

European journal of cancer (Oxford, England : 1990) - 25 Jun 2026

Piotrowska Zofia, Goldberg Sarah B, Goldman Jonathan W, de Langen Adrianus J, Le Xiuning, Okamoto Isamu, Riess Jonathan W, Yu Helena A, Nishino Kazumi, Novello Silvia, Ponce Santiago, Ambrose Helen, Smith Paul E, Tang Kwan Ho, Lehman Jonathan M, Cho Byoung Chul

Abstract excerpt

BACKGROUND: ORCHARD (NCT03944772) was a phase II, biomarker-matched, platform study designed to characterise resistance mechanisms and evaluate novel drug combinations in patients with epidermal growth factor receptor (EGFR)-mutated advanced non-small cell lung cancer (NSCLC) following disease progression on first-line osimertinib. We report final results of the module assessing the efficacy and safety of...

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PMID: 42202477
DOI: 10.1016/j.ejca.2026.116807

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BRAF
EGFR

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