A phase II study (WJOG12819L) to assess the efficacy of osimertinib in patients with EGFR mutation-positive NSCLC in whom systemic disease (T790M-negative) progressed after treatment with first- or second-generation EGFR TKIs and platinum-based chemotherapy.

doi:10.1016/j.lungcan.2023.01.011

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A phase II study (WJOG12819L) to assess the efficacy of osimertinib in patients with EGFR mutation-positive NSCLC in whom systemic disease (T790M-negative) progressed after treatment with first- or second-generation EGFR TKIs and platinum-based chemotherapy.

Lung cancer (Amsterdam, Netherlands) - 1 Mar 2023

Takeda Masayuki, Shimokawa Mototsugu, Nakamura Atsushi, Nosaki Kaname, Watanabe Yasutaka, Kato Terufumi, Hayakawa Daisuke, Tanaka Hiroshi, Takahashi Toshiaki, Oki Masahide, Tachihara Motoko, Fujimoto Daichi, Hayashi Hidetoshi, Yamaguchi Kakuhiro, Yamamoto Shoichiro, Iwama Eiji, Azuma Koichi, Hasegawa Kazuo, Yamamoto Nobuyuki, Nakagawa Kazuhiko

Abstract excerpt

BACKGROUND: Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that is an established standard treatment option for chemotherapy-naive patients with EGFR mutation-positive non-small cell lung cancer (NSCLC). However, of such patients who have received prior treatment with a first- or second-generation EGFR TKI, only approximately half are eligible for...

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PMID: 36731290
DOI: 10.1016/j.lungcan.2023.01.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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