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An NS1-F161L Substitution Determines Host-Driven Virulence Enhancement of H5N6 Avian Influenza Virus in Ducks.

Viruses - 23 Apr 2026

Wu Yuwei, Li Zhifan, Xu Nuo, Lu Zijun, Dong Yurui, Li Kunlin, Bian Ying, Huo Chenzhi, Qin Tao, Chen Sujuan, Yang Hui, Peng Daxin, Liu Xiufan

Abstract excerpt

H5 subtype avian influenza virus (AIV) can infect both chickens and ducks, leading to substantial economic losses. Nevertheless, certain strains cause silent infections in ducks. In this study, a goose-origin clade 2.3.4.4h H5N6 AIV was isolated, which caused high mortality in mixed-gender white leghorn chickens but no deaths in mixed-gender mallard ducks. After independent serial in vitro passage in duck embryo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42198691
DOI: 10.3390/v18050488
PMCID: PMC13211696

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