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Article

Genetic insights and mechanistic parallels in gestational diabetes mellitus and type 2 diabetes.

Nature communications - 15 Jan 2026

Fu Liwan, Han Xiaodi, Wang Yuquan, Hu Yue-Qing

Abstract excerpt

Gestational diabetes mellitus (GDM) has a high heritability and frequently co-occurs with type 2 diabetes (T2D), indicating shared genetic mechanisms. Firstly, we employed RHOGE to ascertain the genetic correlation and putative causal directions between GDM and T2D. Subsequently, the Genotype-Tissue Expression Project v8 eQTls files and the FinnGen R11 dataset were employed to conduct cross-tissue transcriptome...

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Topics

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Share to Diabetes, Gestational
Share to Diabetes Mellitus, Type 2
Share to Pregnancy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Quantitative Trait Loci

Share to Receptors, Cytoplasmic and Nuclear

Share to Transcription Factors

Share to Tripartite Motif Proteins

Share to Ubiquitin-Protein Ligases

Source

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Identifiers

PMID: 41540021
DOI: 10.1038/s41467-025-67385-1
PMCID: PMC12816006

Genes

IFT172
NRBP1
TRIM54

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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