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Article

Validation of an MLV-based SARS-CoV-2 pseudovirus neutralization assay substantiates L455S-mediated antibody escape.

Scientific reports - 20 May 2026

Moll Dominik, Springer David N, Weseslindtner Lukas, Aberle Stephan W, Aberle Judith H, Medits-Weiss Iris, Stiasny Karin

Abstract excerpt

The ongoing evolution of SARS-CoV-2 has generated variants with increased transmissibility and immune evasion, primarily driven by mutations in the receptor-binding domain (RBD). Recent Omicron sublineages, including JN.1, have multiple spike substitutions, including L455S, which is associated with antibody evasion and persists in descendant and currently circulating lineages. While live virus neutralization...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42156873
DOI: 10.1038/s41598-026-53146-7
PMCID: PMC13389565

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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