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Article

Recent advances in genetic predisposition to primary testicular tumors.

Seminars in diagnostic pathology - 1 May 2026

Siegmund Stephanie E

Abstract excerpt

There have been considerable recent advances in our understanding of the genetic predisposition to testicular tumors. In germ cell tumors derived from germ cell neoplasia in situ, which comprise the majority (approximately 95%) of primary testicular neoplasms, research has firmly established a polygenic model of inheritance where risk is not conferred by single high-penetrance genes but rather by the cumulative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42151003
DOI: 10.1016/j.semdp.2026.151011

Genes

APC
CHEK2
DICER1
FH
STK11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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