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Polarized light microscopy reveals distinct spindle phenotypes and outcomes in non-pronuclear zygotes.

Reproductive biomedicine online - 1 Aug 2026

Ma Meng, Liao Xiaoyu, Chen Chen, Yu Lingzhu, Yang Jing, Li Menghui, Zhao Xinxi, Zhao Leiwen, Jin Wei, Lyu Qifeng

Abstract excerpt

RESEARCH QUESTION: Can polarized light microscopy (PLM) spindle phenotypes predict the developmental potential of non-pronuclear (0PN) zygotes? DESIGN: Retrospective observational study including 1266 0PN zygotes and 69,383 two-pronuclei (2PN) zygotes from patients undergoing IVF and embryo transfer treatments in a reproductive centre affiliated to a university hospital from June 2021 to November 2024. Phenotypic...

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Embryo Transfer
Embryonic Development
Fertilization in Vitro
Phenotype
Pregnancy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sperm Injections, Intracytoplasmic

Spindle Apparatus

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PMID: 42150319
DOI: 10.1016/j.rbmo.2025.105422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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