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Article

Reproducible clinical archetypes in acute respiratory failure: a multi-cohort trajectory analysis.

Intensive care medicine - 1 Jul 2026

Marshall Dominic C, Green Ashleigh D, Komorowski Matthieu, Patel Brijesh V, Parbhoo Sonali, Antcliffe David B

Abstract excerpt

PURPOSE: Acute hypoxemic respiratory failure (AHRF) is common and biologically heterogeneous. Static phenotyping at a single time point does not capture illness evolution and risks stage-mixing; reproducible clinical course archetypes may address this. We aimed to identify, externally validate, and predict trajectory classes (TCs) of persistent AHRF. METHODS: We analyzed MIMIC-IV (derivation; n = 3938) and two...

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Identifiers

PMID: 42149243
DOI: 10.1007/s00134-026-08441-2
PMCID: PMC13341900

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