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Article

Site-specific methylation of a TLR1 promoter SNP impedes CREB binding to impair antibacterial immunity in grass carp.

Journal of immunology (Baltimore, Md. : 1950) - 14 May 2026

Lv Maolin, Li Wenxing, Xu Yuezong, Chen Guanyu, Wang Shijie, Lu Yizhong, Su Jianguo

Abstract excerpt

As the most abundantly farmed freshwater fish species, grass carp (Ctenopharyngodon idella) faces a serious threat from Aeromonas hydrophila infection, underscoring the critical need to understand the genetic basis of disease resistance for selective breeding. This study deciphered the functional association and mechanism between polymorphisms in the CiTLR1 gene and resistance to A. hydrophila. CiTLR1 shows a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42145081
DOI: 10.1093/jimmun/vkag065

Genes

TLR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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