Melatonin Levels in 89 Individuals With Smith Magenis Syndrome.

Abstract excerpt

In patients with Smith-Magenis syndrome (SMS), an inverted circadian rhythm of melatonin (MT) contributes to the sleep disturbance. Standard treatment of sleep disturbance with MT often leads to extremely high daytime MT levels, resulting in even more sleep disorders. We therefore retrospectively evaluated the MT data of 89 SMS patients. Mean MT levels in participants on exogenous MT were significantly higher...

Topics

• Humans
• Melatonin
• Female
• Cytochrome P-450 CYP1A2
• Smith-Magenis Syndrome
• Male
• Adolescent