Article
Inversion of the circadian rhythm of melatonin in the Smith-Magenis syndrome.
The Journal of pediatrics - 1 Jul 2001
De Leersnyder H, De Blois M C, Claustrat B, Romana S, Albrecht U, Von Kleist-Retzow J C, Delobel B, Viot G, Lyonnet S, Vekemans M, Munnich A
Abstract excerpt
OBJECTIVE: The objective was to determine the circadian rhythm of melatonin in the Smith-Magenis syndrome (SMS), which causes behavioral problems and sleep disturbance. STUDY DESIGN: Questionnaires, sleep consultations, and sleep diaries were obtained in 20 children with SMS (9 girls, 11 boys aged 4 to 17 years). Actigraphy, electroencephalography, and the circadian variations of plasma melatonin, cortisol, and...
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