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Article

Aripiprazole and trazodone cause elevations of 7-dehydrocholesterol in the absence of Smith-Lemli-Opitz Syndrome.

Molecular genetics and metabolism - 1 Jan 2000

Hall Patricia, Michels Virginia, Gavrilov Dimitar, Matern Dietrich, Oglesbee Devin, Raymond Kimiyo, Rinaldo Piero, Tortorelli Silvia

Abstract excerpt

Screening for Smith-Lemli-Opitz Syndrome (SLOS) using elevated 7-dehydrocholesterol (7DHC) as a marker is sensitive, but not always specific. Elevations of 7DHC can be seen in patients who do not have a defect in 7-dehydrocholesterol reductase. These results have often been attributed to medication artifacts, but specific causes have not been well reported. We examined the medical records of patients with...

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Identifiers

PMID: 23628460
DOI: 10.1016/j.ymgme.2013.04.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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