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Article

Urothelial Carcinoma in Children and Young Adults is Characterized by Higher Frequency of HRAS Mutations and Lower Prevalence of TERT Promoter and FGFR3 Mutations.

The American journal of surgical pathology - 1 Sept 2026

Cheng Liang, Tan Hui Min, Lopez-Beltran Antonio, Montironi Rodolfo, Osunkoya Adeboye O, Cheng Michael, Amin Ali, Cimadamore Alessia, Zhang Shaobo

Abstract excerpt

Urothelial carcinoma in young patients is exceedingly rare, and their molecular oncogenesis is not well understood. In this study, we investigated the frequencies of HRAS, TERT promoter, and FGFR3 mutations in a cohort of 31 urothelial neoplasms occurring in children and young adults, to understand their molecular characteristics and underpinnings. Thirty-one urothelial neoplasms were identified in patients less...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins p21(ras)

Share to Receptor, Fibroblast Growth Factor, Type 3

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Source

Identifiers

PMID: 42138113
DOI: 10.1097/PAS.0000000000002566

Genes

FGFR3
HRAS
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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