Periprostatic adipose tissue-derived adipokine profile in prostate cancer patients reveals two distinct molecular phenotypes linked to obesity-related comorbidities: multifaceted role of lipocalin-2.

doi:10.1186/s12964-026-02925-w

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Periprostatic adipose tissue-derived adipokine profile in prostate cancer patients reveals two distinct molecular phenotypes linked to obesity-related comorbidities: multifaceted role of lipocalin-2.

Cell communication and signaling : CCS - 14 May 2026

Pérez-Gómez Jesús M, Prats-Escribano Antonio, Gil-Duque Ignacio, Arroyo-Millán Laura, Huertas-Cabrera Hugo, Núñez-Santos Miguel A, López-Ruiz Daniel J, Mata-Ordoñez Fernando, González-Serrano Teresa, Ortea Ignacio, Porcel-Pastrana Francisco, Álvarez-Benito Marina, Planque Mélanie, Carrasco-Valiente Julia, Gómez-Gómez Enrique, Guzmán-Ruiz Rocío, Fuentes-Fayos Antonio C, Fendt Sarah-Maria, Gahete Manuel D, Sarmento-Cabral André, Malagón María Del Mar, Luque Raúl M

Abstract excerpt

BACKGROUND: Prostate cancer (PCa) is a hormone-dependent tumor and one of the most prevalent cancers in men worldwide. PCa progression is influenced by its interaction with the surrounding tumor microenvironment, highlighting the role of periprostatic adipose tissue (PPAT), which modulates PCa behavior through the secretion of bioactive molecules (e.g., adipokines). However, the influence of this complex cell...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42135849
DOI: 10.1186/s12964-026-02925-w
PMCID: PMC13277168

Genes

LCN2
PPAT
SLC22A17
PC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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