Evaluation of Sensititre YeastOne for antifungal susceptibility testing of Candida (Candidozyma) auris: misclassification of FKS1 mutants and overestimation of caspofungin resistance in a global collection of isolates.

Abstract excerpt

Sensititre YeastOne (SYO) is a widely used commercial colorimetric assay, yet its performance for C. auris remains uncertain. We tested 113 global isolates, including 24 FKS1 mutants, using SYO and the Clinical and Laboratory Standards Institute (CLSI) broth microdilution in parallel. Agreement (±1 twofold dilution) and categorical agreement (CA) were assessed using Centers for Disease Control and Prevention...

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