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Article

How Epigenetics Bridges Genes and Environment: A Multiomics Evidence Chain in Congenital Diaphragmatic Hernia.

Birth defects research - 1 May 2026

Gao Yunshan, Zhu Xian, Dai Rutao, Zhang Xichen, Ma Yongyu, Dao Ya, Chen Junru, Yang Shiwu, Wu Jun

Abstract excerpt

BACKGROUND/OBJECTIVES: Congenital diaphragmatic hernia (CDH) is a severe developmental anomaly with high etiological heterogeneity. Although numerous susceptibility genes have been identified, genetic factors alone fail to explain the full disease risk. Epidemiological data highlight the contribution of environmental exposures. Epigenetic regulation provides a crucial link bridging genetic predisposition and...

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Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene-Environment Interaction

Share to Genetic Predisposition to Disease

Share to Hernias, Diaphragmatic, Congenital

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Identifiers

PMID: 42125881
DOI: 10.1002/bdr2.70047
PMCID: PMC13169189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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