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Article

Integrated Host Genetics and Skin Microbiome Profiling Suggest an HLA-C-Peptostreptococcus Axis in Psoriasis.

International journal of molecular sciences - 4 May 2026

Seifert Oliver, Assarsson Malin, Manoharan Lokeshwaran, Söderman Jan

Abstract excerpt

Psoriasis is a chronic immune-mediated disease driven by genetic susceptibility and environmental factors, including microbial exposure. While HLA-C-linked variants represent the strongest genetic risk factors, their relationship with the cutaneous microbiome remains incompletely understood. This study aimed to investigate host-microbiome interactions in psoriasis through integrative multi-omics analysis. Skin...

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Share to Genetic Predisposition to Disease
Share to HLA-C Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Share to RNA, Ribosomal, 16S

Source

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Identifiers

PMID: 42123693
DOI: 10.3390/ijms27094116
PMCID: PMC13163479

Genes

DIABLO
ERAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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