Article
Detection of drug resistance mutations and spoligotype mapping in Mycobacterium tuberculosis using deeplex sequencing, including novel and uncharacterized spoligotypes.
Archives of microbiology - 9 May 2026
Tovar-Nieto Andrea Michel, Rivas-Santiago Bruno, Trujillo-Paez Juan Valentin, Núñez-Contreras Jesús, Gonzalez-Muñiz Oscar E, Gonzalez-Curiel Irma E, Huerta-Elias Jaime E, Sevilla-Fuentes Samuel, López-Ramos Juan Ernesto, Rodríguez-Carlos Adrián
Abstract excerpt
Tuberculosis (TB) remains one of the most significant infectious diseases globally, particularly affecting low- and middle-income countries, including Mexico. Its persistence is driven, among other factors, by the emergence of drug-resistant strains and the complex genetic diversity of Mycobacterium tuberculosis (M.tb). Accurate identification and molecular characterization of circulating strains are essential...
Topics
- Mycobacterium tuberculosis
- Mutation
- Mexico
- Antitubercular Agents
- High-Throughput Nucleotide Sequencing
- Humans
- Tuberculosis, Multidrug-Resistant
- Drug Resistance, Bacterial