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Article

FLP-15 functions through the GPCR NPR-3 to regulate local and global search behaviours in Caenorhabditis elegans.

Communications biology - 5 May 2026

Bhat Umer Saleem, Surendran Siju, H Sharanya, Liu Jun, Xu Yun, Tasnim Namra, Abbas Mohd Faraz, Bhardwaj Ashwani, Scholz Monika, Babu Kavita

Abstract excerpt

The transition from well-fed to food-deprived conditions in C. elegans triggers a stereotypic exploration behaviour characterised by a temporal decrease in reorientation frequency. In this study we conduct a screen of neuropeptide mutants and identify several candidates involved in modulating this behaviour. Among these, the neuropeptide FLP-15 emerges as a key regulator. Our observations reveal that FLP-15...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42082704
DOI: 10.1038/s42003-026-10188-x
PMCID: PMC13346541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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